We Pigs News for 08-06-2018

American researchers transplant bioengineered lungs into pigs without complication

WASHINGTON, Aug. 1 – American scientists reported on Wednesday in the journal Science Translational Medicine that they bioengineered lungs and transplanted them into adult pigs with no medical complication. Joan Nichols and Joaquin Cortiella from the University of Texas Medical Branch provided details of how they bioengineered human lungs in a lab, first made in 2014, but this time going without complications in the pigs as part of standard preclinical testing. The cells used to produce each bioengineered lung came from a single lung removed from each of the study animals. The lung scaffold was placed into a tank filled with a carefully blended cocktail of nutrients and then the animals’ own cells were added to the scaffold following a carefully designed protocol or recipe. The bioengineered lungs were grown in a bioreactor for 30 days prior to transplantation. 

All of the pigs that received a bioengineered lung stayed healthy. As early as two weeks post-transplant, the bioengineered lung had established the strong network of blood vessels needed for the lung to survive. There was no signs of pulmonary edema, which is usually a sign of the vasculature not being mature enough, according to the researchers. The study showed that the bioengineered lungs continued to develop post-transplant without any infusions of growth factors, and the body provided all of the building blocks that the new lungs needed. The researchers said that the focus of the study was to learn how well the bioengineered lung adapted and continued to mature within a large, living body. 

They didn’t evaluate how much the bioengineered lung provided oxygenation to the animal. The researchers said that with enough funding, they could grow lungs to transplant into people in compassionate use circumstances within five to 10 years. 

Keywords: [“lung”,”bioengineered”,”scaffold”]
Source: http://www.xinhuanet.com/english/2018-08/02/c_137362266.htm

The UTMB Newsroom

GALVESTON, Texas – A research team at the University of Texas Medical Branch at Galveston have bioengineered lungs and transplanted them into adult pigs with no medical complication. In 2014, Joan Nichols and Joaquin Cortiella from The University of Texas Medical Branch at Galveston were the first research team to successfully bioengineer human lungs in a lab. A support scaffold was created using a lung from an unrelated animal that was treated using a special mixture of sugar and detergent to eliminate all cells and blood in the lung, leaving only the scaffolding proteins or skeleton of the lung behind. This is a lung-shaped scaffold made totally from lung proteins. The cells used to produce each bioengineered lung came from a single lung removed from each of the study animals. 

The lung scaffold was placed into a tank filled with a carefully blended cocktail of nutrients and the animals’ own cells were added to the scaffold following a carefully designed protocol or recipe. The bioengineered lungs were grown in a bioreactor for 30 days prior to transplantation. Animal recipients were survived for 10 hours, two weeks, one month and two months after transplantation, allowing the research team to examine development of the lung tissue following transplantation and how the bioengineered lung would integrate with the body. All of the pigs that received a bioengineered lung stayed healthy. As early as two weeks post-transplant, the bioengineered lung had established the strong network of blood vessels needed for the lung to survive. 

They didn’t evaluate how much the bioengineered lung provided oxygenation to the animal. The researchers said that with enough funding, they could grow lungs to transplant into people in compassionate use circumstances within five to 10 years. 

Keywords: [“lung”,”bioengineer”,”animal”]
Source: https://www.utmb.edu/newsroom/article11815.aspx

2018 Asian American International Film Festival

Five lives suddenly collide when pig farmer Old Wang’s entire stock dies en masse and turns up in Shanghai’s waterways, setting off a public health crisis. Cathy Yan’s DEAD PIGS assembles a cast of characters who embody dreamers, deadbeats, and ambitious movers who must answer the question of what the individual should do in a country relentlessly marching away from its past and toward progress. Old Wang is a longtime pig farmer who invests his money in China’s burgeoning tech industry. Candy Wang is a hairstylist facing off mega-developer Golden Happiness Properties, which wants to evict Candy from her ancestral land for a new development. American expat Sean Landry is the chief architect of this project with Golden Happiness. 

Wang Zhen is just trying to make ends meet, kowtowing to the city’s elite youth as a waiter in a roast pig restaurant bar. There, he meets Xia Xia, the wealthy and spoiled child of a successful businessman. Though they may not have met yet, the motley crew of DEAD PIGS is already bound together by simply existing in modern China. Yan’s DEAD PIGS is a portrait of humanity in a country that has adopted an attitude of modernizing at all costs. Full of dark images, but paired with a jaunty, delightful humor, DEAD PIGS veritably bounces in contrast to the social realism that has come to characterize popular arthouse in China today. 

Her feature film debut, DEAD PIGS, premiered at the 2018 Sundance Film Festival in the World Cinema Dramatic Competition and won a Special Jury Prize for Ensemble Acting. She is next set to direct Margot Robbie in a girl gang movie featuring the character Harley Quinn based on the Birds of Prey comic books for DC/Warner Brothers. 

Keywords: [“pig”,”DEAD”,”Wang”]
Source: http://aaiff.org/2018/events/dead-pigs-encore-special

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